109
22
15
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T1349 |
5-Fluorouridine
|
Others; DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Others |
5-Fluorouridine 是一种 5-fluorouracil 的代谢物,具有抗癌作用。它对 L1210 细胞的生长具有细胞毒性作用,其作用的 IC50值为 2 nM。它能抑制人结肠癌细胞 rRNA 的合成。 | |||
T0984 |
5-Fluorouracil
5-FU,Fluorouracil,5-氟脲嘧啶,NSC 19893,5-Fluoracil,氟尿嘧啶 |
Apoptosis; Nucleoside Antimetabolite/Analog; HIV Protease; DNA/RNA Synthesis; Endogenous Metabolite | Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology; Proteases/Proteasome |
5-Fluorouracil (5-FU) 是一种尿嘧啶类似物,一种 DNA 合成抑制剂。5-Fluorouracil 具有抗肿瘤活性,通过抑制胸苷酸合成酶影响嘧啶的合成。5-Fluorouracil 可以引起细胞凋亡和自噬。 | |||
T8138 |
Phenazine methylsulfate
5-甲基吩嗪硫酸甲酯,Phenazine methosulfate |
Apoptosis; Antibacterial; Antibiotic | Apoptosis; Microbiology/Virology |
Phenazine methylsulfate 是一种自由基产生剂。 它已被用作细胞活力测定中的电子转移反应物。 它在还原剂 NADPH 存在下诱导 ssDNA 断裂形成。它在碱性彗星试验和细胞凋亡中诱导氧化性 DNA 损伤。 | |||
T23450 |
TCS PrP Inhibitor 13
5-(4-Nitrophenyl)-2-Phenyl-4H-Pyrazol-3-One |
Others | Others |
TCS PrP Inhibitor 13 (5-(4-Nitrophenyl)-2-Phenyl-4H-Pyrazol-3-One) 是一种抗朊病毒剂,可抑制蛋白酶抗性朊病毒蛋白的积累。它诱导神经鞘瘤细胞调亡,在ScN2a 和F3细胞株中均显示IC50值为3 nM。 | |||
T16087 |
Quiflapon
喹夫拉朋,MK-591 |
Apoptosis; FLAP | Apoptosis; Immunology/Inflammation |
Quiflapon (MK-591) 是一种选择性和特异性的FLAP 抑制剂,可诱导细胞凋亡。它也是口服白三烯生物合成抑制剂,在完整的人和诱导的大鼠多形核白细胞 PMNLs 中,其IC50值分别为 3.1 nM 和 6.1 nM。 | |||
T8742 |
G5-7
JAK2 inhibitor G5-7 |
Apoptosis; JAK | Angiogenesis; Apoptosis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells |
JAK2 inhibitor G5-7 (JAK2 inhibitor G5-7) 是具有口服活性的JAK2变构抑制剂,可通过结合到 JAK2,选择性的抑制JAK2介导的 EGFR 和 STAT3 的磷酸化和激活。它诱导细胞周阻滞和诱导凋亡、具有抗血管生成活性。它有用于胶质瘤研究的潜能。 | |||
T6371 |
AGK2
2-氰基-3-[5-(2,5-二氯苯基)-2-呋喃基]-N-5-喹啉基-2-丙烯酰胺 |
Apoptosis; Sirtuin | Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair |
AGK2 是一种选择性SIRT2抑制剂,其IC50值为 3.5 μM。它抑制 SIRT1 和 SIRT3,IC50值分别为 30 和 91 μM。 | |||
T0365 |
Thioridazine hydrochloride
盐酸硫利达嗪,Mellaril,Aldazine |
Apoptosis; Potassium Channel; Dopamine Receptor; 5-HT Receptor; Antibacterial; Adrenergic Receptor; Autophagy | Apoptosis; Autophagy; GPCR/G Protein; Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience |
Thioridazine hydrochloride (Mellaril) 是一种多巴胺受体D2家族蛋白的拮抗剂,有抗精神病和抗焦虑活性。它也是一种PI3K-Akt-mTOR 信号通路的抑制剂,具有抗血管生成作用。它在多种类型的癌细胞中显示出抗增殖和凋亡诱导作用,对靶向癌症干细胞具有特异性。 | |||
T11571 |
HLY78
4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine |
Wnt/beta-catenin | Cytoskeletal Signaling; Stem Cells |
HLY78 (4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine) 是 Wnt/β-catenin 信号通路的激活剂,通过靶向通道中 Axin 的 DIX 域,增强 Axin-LRP6 交联,诱导 Wnt 信号转导。 | |||
T2258 |
VER-50589
VER50589,5-(5-氯-2,4-二羟基苯基)-n-乙基-4-(4-甲氧基苯基)异噁唑-3-羧酰胺 |
Apoptosis; HSP | Apoptosis; Cytoskeletal Signaling; Metabolism |
VER-50589 是一种 Hsp90抑制剂,Kd 值为 4.5 nM,IC50值为 21 nM。 | |||
T6916 |
OICR-9429
OICR 9429 |
Histone Methyltransferase; JAK | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells |
OICR-9429 是一个新颖的相互作用的小分子Wdr5-MLL 拮抗剂,IC50是 5 uM,在体外抑制急性髓性白血病细胞。 | |||
T6611 |
NSC697923
2-[(4-methylphenyl)sulfonyl]-5-nitrofuran |
E1/E2/E3 Enzyme | Ubiquitination |
NSC-697923 (2-[(4-methylphenyl)sulfonyl]-5-nitrofuran), a potent inhibitor of UBE2N (ubiquitin-conjugating enzyme E2 N, Ubc13), exhibits its role in inducing cell death in neuroblastoma (NB) cells through two distinct mechanisms. In p53 wild-type NB cells, NSC-697923 promotes the nuclear importation of p53, thereby triggering cell death. Meanwhile, in p53 mutant NB cells, NSC-697923 activates the JNK-mediated apoptotic pathway, leading to cell death. Additionally, NSC-697923 inhibits DNA damage ... | |||
T0964 |
Floxuridine
氟尿苷,5-Fluorouracil 2'-deoxyriboside,FUDR,Deoxyfluorouridine,NSC 27640 |
Apoptosis; Nucleoside Antimetabolite/Analog; Others; DNA/RNA Synthesis; Antibacterial; HSV | Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Others |
Floxuridine (FUDR) 是一种嘧啶类似物,也是一种抗肿瘤代谢物。它抑制胸苷酸合成酶,导致 DNA 合成中断和细胞毒性。它是一种可诱导细胞凋亡的金黄色葡萄球菌感染抑制剂 ,具有抗HSV 和CMV 病毒的作用。 | |||
T6893 |
MK-886
MK886,L 663536 |
Apoptosis; Leukotriene Receptor; COX; PPAR; FLAP | Apoptosis; DNA Damage/DNA Repair; GPCR/G Protein; Immunology/Inflammation; Metabolism; Neuroscience |
MK-886 (L 663536)是一种细胞可渗透的,具有口服活性的 FLAP (IC50为 30 nM) 和白三烯生物合成 (完整白细胞和人全血中的IC50分别为 3 nM 和 1.1μM) 的抑制剂。它也是一种非竞争性PPARα拮抗剂,可以诱导细胞凋亡。 | |||
T1090 |
Perphenazine
Perphenazin,Etaperazine,Trilafon,奋乃静 |
CaMK; Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Perphenazine (Trilafon) 是吩噻嗪衍生物和多巴胺拮抗剂,具有止吐和抗精神病特性。它能够抑制5-HT2A 受体,α1A 肾上腺素能受体,多巴胺D2、D3、D2L 受体,以及组胺H1受体,对应的Ki 值分别为5.6、10、0.765、0.13、3.4 和 8 nM。 | |||
T6525 |
GW 5074
GW5074,3-(3,5-二溴-4-羟基苯亚甲基)-5-碘-1,3-二氢吲哚-2-酮,Raf1 Kinase Inhibitor I |
Apoptosis; Raf | Apoptosis; MAPK |
GW 5074 (Raf1 Kinase Inhibitor I) 是一种有效且特异性的 c-Raf 抑制剂,IC50值为 9 nM。 它对 JNK1/2/3、MEK1、MKK6/7、CDK1/2、c-Src、p38 MAP、VEGFR2 或 c-Fms 的活性没有影响。 | |||
T1567 |
Olanzapine
LY170053,奥氮平 |
Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor; AChR | GPCR/G Protein; Neuroscience |
Olanzapine (LY170053) 是一种非典型抗精神病药,目前用于治疗精神分裂症和双相情感障碍。 | |||
T4263 |
BAY 61-3606
2-[[7-(3,4-二甲氧基苯基)咪唑并[1,2-C]嘧啶-5-基]氨基]-3-吡啶甲酰胺,Syk inhibitor IV |
Apoptosis; Syk | Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors |
BAY 61-3606 (Syk inhibitor IV) 是一种具有口服活性的,ATP 竞争性的可逆选择性Syk 抑制剂。它作用于乳腺癌细胞,通过下调 Mcl-1 促进 TRAIL 诱导的细胞凋亡。它降低神经母细胞瘤细胞中的 ERK1/2 和 Akt 磷酸化,也降低 K-rn 细胞裂解物中 Syk 磷酸化。 | |||
T8656 |
CAY10404
3-(4-METHYLSULPHONYLPHENYL)-4-PHENYL-5-T |
Apoptosis; Akt; COX | Apoptosis; Cytoskeletal Signaling; Immunology/Inflammation; Neuroscience; PI3K/Akt/mTOR signaling |
CAY10404 (3-(4-METHYLSULPHONYLPHENYL)-4-PHENYL-5-T) 是一种有效且高度选择性的 COX-2 和 COX-1 抑制剂。 它还是 PKB/Akt 和 MAPK 信号通路的有效抑制剂,可诱导 NSC-LC 细胞凋亡,具有镇痛、抗炎和抗癌活性。 | |||
T22051 |
BU 224 hydrochloride
|
Imidazoline Receptor | Neuroscience |
BU 224 hydrochloride 是一种选择性的咪唑啉 I(2) 结合位点配体,具有镇痛和抗抑郁样活性。 | |||
T8445 |
PU02
PU-02,6-[(1-Naphthalenylmethyl)thio]-9H-purine |
Apoptosis; 5-HT Receptor | Apoptosis; GPCR/G Protein; Neuroscience |
PU02 (6-[(1-Naphthalenylmethyl)thio]-9H-purine) 是5-HT3受体的负变构调节剂,是 6-MP 的一个衍生物。它在 HEK293 细胞测得的转染 5-HT3A 和 5-HT3AB 受体后的 IC50值分别为 0.36 和 0.73 μM。 | |||
T5045 |
GSK4112
1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate,SR6452 |
Autophagy | Autophagy |
GSK4112 (SR6452) 是一种 Rev-erbα 激动剂,EC50 为 0.4 μM。它也是一种用于核血红素受体 Rev-erbα 的细胞生物学的小分子化学探针。 | |||
T9373 |
DCH36_06
(5E)-1-(3-chloro-4-methylphenyl)-5-[(2E)-3-(furan-2-yl)prop-2-en-1-ylidene]-2-thioxodihydropyrimidine-4,6(1H,5H)-dione |
Apoptosis; Epigenetic Reader Domain; Histone Acetyltransferase | Apoptosis; Chromatin/Epigenetic |
DCH36_06 ((5E)-1-(3-chloro-4-methylphenyl)-5-[(2E)-3-(furan-2-yl)prop-2-en-1-ylidene]-2-thioxodihydropyrimidine-4,6(1H,5H)-dione) 是一种选择性p300/CBP 抑制剂,介导 p300/CBP 抑制导致白血病细胞中 H3K18 的低乙酰化,有抗肿瘤活性,对p300和CBP 的IC50分别为 0.6 μM 和 3.2 μM。 | |||
T16079 |
Mirodenafil
米罗那非,SK3530 |
PDE | Metabolism |
Mirodenafil 是一种磷酸二酯酶5(PDE-5)抑制剂,可用于勃起功能紊乱的研究。 | |||
T8505 |
SC-236
4-(5-(4-氯苯基)-3-(三氟甲基)-1H-,Sc 236 |
Apoptosis; COX; PPAR | Apoptosis; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Neuroscience |
SC-236 (Sc 236) 是一种具有口服活性的COX-2特异性抑制剂和PPARγ激动剂。它可通过 c-Jun 氨基端抑制激活蛋白-1活性,在小鼠模型中通过抑制 ERK 的磷酸化发挥抗炎作用。 | |||
T3602 |
D-Pantothenic acid sodium
泛酸钠,D-Pantothenate Sodium,D-Pantothenic acid sodium salt,Sodium pantothenate,D-泛酸钠,vitamin B5 sodium |
Apoptosis; Others | Apoptosis; Others |
D-Pantothenic acid sodium (vitamin B5 sodium) 是一种必需的微量营养素,作为辅酶 A 的前体,在调节碳水化合物,脂质,蛋白和核酸代谢中发挥关键作用。 | |||
T4215 |
TCS-PIM-1-4a
5-[[3-(三氟甲基)苯基]亚甲基]-2,4-噻唑烷二酮,SMI-4a |
Apoptosis; Pim | Apoptosis; Chromatin/Epigenetic; JAK/STAT signaling |
TCS-PIM-1-4a (SMI-4a) 是一种泛-Pim 激酶抑制剂,可通过激活 AMPK 来阻断 mTORC1的活性。它可杀死多种髓样和淋巴样细胞系,IC50值为 0.8 μM 至 40 μM。 | |||
T8934 |
(6R)-FR054
(3AR,7AR)-5-(乙酰氧基甲基)-2-甲基-5,6,7,7A-四氢-3AH-吡喃并[3,2-D]噁唑-6,7-叉基二醋酸盐,FR054 |
Apoptosis; Others | Apoptosis; Others |
(6R)-FR054 是己糖胺生物合成途径酶 PGM3 的抑制剂,具有显著的抗乳腺癌作用。 | |||
T6498 |
Fenoprofen calcium hydrate
Feprona dihydrate,Fenoprofen calcium salt dihydrate,Progesic dihydrate,非诺洛芬钙二水合物 |
Apoptosis; Others; COX | Apoptosis; Immunology/Inflammation; Neuroscience; Others |
Fenoprofen calcium hydrate (Progesic dihydrate) 是一非甾体类抗炎症化合物。 | |||
T8825 |
Capmatinib 2HCl.H2O
INCB28060 2HCl.H2O,INC-280 2HCl.H2O,NVP-INC280 2HCl.H2O |
c-Met/HGFR | Tyrosine Kinase/Adaptors |
Capmatinib 2HCl.H2O (NVP-INC280 2HCl.H2O) 是一种具有潜在抗肿瘤活性的原癌基因 c-Met (HGFR) 的口服生物可利用抑制剂。 | |||
T6173 |
BI 2536
4-[[(7R)-8-环戊基-7-乙基-5,6,7,8-四氢-5-甲基-6-氧代-2-喋啶基]氨基]-3-甲氧基-N-(1-甲基-4-哌啶基)苯甲酰胺 |
Apoptosis; Epigenetic Reader Domain; PLK | Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic |
BI 2536 一种是PLK1和BRD4的双抑制剂,IC50分别为 0.83 和 25 nM。它抑制 IFNB 干扰素 β 基因转录。 | |||
T8416 |
Capmatinib xHCl
INCB28060,Capmatinib hydrochloride(free base),INC280 |
c-Met/HGFR | Tyrosine Kinase/Adaptors |
Capmatinib xHCl (INCB28060) 是一种有效的、口服活性的、选择性的和 ATP 竞争性 c-Met 激酶抑制剂,有效地阻断体外激酶活性 (IC50 = 0.13 nM) 以及在细胞中的组成型或 HGF 刺激活性(IC50 值范围从 0.3 到1.1纳米)。 | |||
T1963 |
Capmatinib
NVP-INC280,INC-280,卡马替尼,INCB28060 |
Apoptosis; c-Met/HGFR | Apoptosis; Tyrosine Kinase/Adaptors |
Capmatinib (INCB28060) 是一种具有口服活性的,选择性的,ATP 竞争性的c-Met 激酶抑制剂,IC50值为0.13 nM。它有效抑制 c-Met 依赖性肿瘤细胞的增殖和迁移,可诱导细胞凋亡,有抗肿瘤活性。 | |||
T4310 |
Prexasertib
5-[[5-[2-(3-氨基丙氧基)-6-甲氧基苯基]-1H-吡唑-3-基]氨基]-2-吡嗪甲腈,LY2606368 |
Apoptosis; Chk | Apoptosis; Cell Cycle/Checkpoint |
Prexasertib (LY2606368) 是一种具有潜在抗肿瘤活性的检查点激酶 1 抑制剂。它可引起双链 DNA 断裂和复制突变,导致细胞凋亡。 | |||
TQ0126 |
Mirodenafil dihydrochloride
SK-3530 dihydrochloride,米罗那非二盐酸盐 |
PDE | Metabolism |
Mirodenafil dihydrochloride 是一种磷酸二酯酶5(PDE-5)抑制剂,可作用于勃起功能紊乱的研究。 | |||
T14511 |
BAY1082439
N-[8-[[(2R)-2-羟基-3-(吗啉-4-基)丙基]氧基]-7-甲氧基-2,3-二氢咪唑并[1,2-C]喹唑啉-5-基]-2-甲基吡啶-3-甲酰胺 |
Apoptosis; PI3K | Apoptosis; PI3K/Akt/mTOR signaling |
BAY1082439 是一种具有口服活性的,选择性 PI3Kα/β/δ抑制剂。它也能抑制 PIK3CA 的突变形式,它对抑制 Pten 丢失的前列腺癌的生长有很强的作用。 | |||
T4260 |
Capmatinib 2HCl
INC-280 2HCl,INCB28060盐酸盐,INCB28060 2HCl |
c-Met/HGFR | Tyrosine Kinase/Adaptors |
Capmatinib 2HCl (INC-280 2HCl) 是一种新型的 ATP 竞争性 c-MET 激酶抑制剂,IC50 为 0.13 nM。它具有皮摩尔酶效,对 c-MET 具有高度特异性,选择性超过 10, 000 倍一大组人类激酶。该抑制剂在 c-MET 依赖性肿瘤细胞系中有效阻断 c-MET 磷酸化和其关键下游效应子的激活。因此,它在体外有效抑制 c-MET 依赖性肿瘤细胞增殖和迁移,并有效诱导细胞凋亡。 | |||
T20792 |
W-7 hydrochloride
N-(6-氨基己基)-5-氯-1-萘磺胺盐酸盐,W 7 HCl,W7 HCl,W-7 HCl |
CaMK; Apoptosis; Myosin; PDE | Apoptosis; Cytoskeletal Signaling; Metabolism; Neuroscience |
W-7 hydrochloride (W-7 HCl) 是一种选择性的钙调蛋白拮抗剂。它抑制Ca2+-钙调蛋白依赖性磷酸二酯酶和肌球蛋白轻链激酶,IC50值分别为 28 μM 和 51 μM。它可诱导细胞凋亡,具有抗癌活性。 | |||
T2287 |
PIK-75 hydrochloride
PIK-75 HCl,2-甲基-5-硝基苯磺酸 [(6-溴咪唑并[1,2-a]吡啶-3-基)亚甲基]甲基肼盐酸盐,PIK-75 |
Apoptosis; DNA-PK; PI3K | Apoptosis; DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling |
PIK-75 hydrochloride (PIK-75 HCl) 是一种可逆的 DNA-PK 和 p110α-选择性抑制剂,抑制 DNA-PK,p110α和 p110γ,可诱导凋亡。 | |||
T15378 |
Gemcitabine elaidate
Gemcitabine 5'-elaidate,反油酸吉西他滨,吉西他滨反油酸酯,Gemcitabine (elaidate),CO-101,CP-4126 |
Apoptosis; Nucleoside Antimetabolite/Analog; Autophagy | Apoptosis; Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
Gemcitabine elaidate (CP-4126) 是 Gemcitabine 的亲脂性前药。它通过酯酶转化为 Gemcitabine 以被磷酸化。它具有抗肿瘤活性。 | |||
T21017 |
5'-Amino-5'-deoxyadenosine
5' Amino 5' deoxyadenosine,5'Amino5'deoxyadenosine,Nsc 238990,NH2dAdo |
Apoptosis; Adenosine Receptor | Apoptosis; GPCR/G Protein; Neuroscience |
5'-Amino-5'-deoxyadenosine (NH2dAdo) 是一种针对惰性淋巴系统恶性肿瘤的腺苷激酶抑制剂,具有抗肿瘤和抗癌作用。5'-Amino-5'-deoxyadenosine 的抗癌机制通过抑制 DNA 合成,诱导细胞凋亡 (apoptosis) 等来实现。 | |||
T27582 |
iCRT-5
iCRT 5,iCRT5 |
Apoptosis; Wnt/beta-catenin | Apoptosis; Cytoskeletal Signaling; Stem Cells |
iCRT-5 是一种有效的 Wnt 通路抑制剂。iCRT-5 具有抗增殖活性,可以阻断 Wnt/β-catenin 表达,诱导细胞凋亡。iCRT-5 可用于研究多发性骨髓瘤。 | |||
T77763 |
Wu-5
|
DUB | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Ubiquitination |
Wu-5 是一种有效的 USP10 抑制剂,对 FLT3 和 AMPK 通路有抑制作用,促使 FLT3-ITD 分解并诱导细胞凋亡(apoptosis)。 | |||
T12617 |
(R)-CR8 trihydrochloride
CR8, (R)-Isomer trihydrochloride |
Apoptosis; CDK | Apoptosis; Cell Cycle/Checkpoint |
(R)-CR8 trihydrochloride (CR8, (R)-Isomer trihydrochloride) 是一种 CDK1/2/5/7/9 抑制剂,可作为分子胶降解剂,具有神经保护活性,可诱导细胞凋亡。 | |||
T77528 |
5-LOX-IN-2
|
Apoptosis; Lipoxygenase | Apoptosis; Metabolism |
5-LOX-IN-2 是 一种 5-脂氧合酶抑制剂 (5-LOX )抑制剂,从体外实验测得的IC50 值为 0.33 μM。5-LOX-IN-2 以剂量依赖的方式抑制 5-LOX发挥作用。5-LOX-IN-2 可降低肾癌细胞的细胞活性并诱导凋亡 (apoptosis),可用于研究癌症。 | |||
T81417 |
PP5-IN-1
|
Apoptosis; Phosphatase | Apoptosis; Metabolism |
PP5-IN-1 是一种具有有效性和竞争性的丝氨酸/苏氨酸蛋白磷酸酶-5 (PP5) 抑制剂,具有潜在的抗癌活性,可诱导癌细胞凋亡。 | |||
T2383 |
Panobinostat
帕比司他,NVP-LBH589,LBH589 |
Apoptosis; HIV Protease; HDAC; Autophagy | Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; Microbiology/Virology; Proteases/Proteasome |
Panobinostat (NVP-LBH589) 是一种广谱的 HDAC 抑制剂 (IC50=5 nM),具有口服活性和非选择性。Panobinostat 具有抗肿瘤活性,可以诱导细胞凋亡和自噬。 | |||
T15239 |
Epristeride
SKF105657,ONO-9302 |
Apoptosis; Reductase | Apoptosis; Endocrinology/Hormones; Metabolism |
Epristeride (ONO-9302) 是具有口服活性、选择性和非竞争性类固醇 5-α-还原酶亚型2抑制剂,抑制SR 同工酶 2。Episteride 可减小前列腺大小并改善良性前列腺增生男性的症状。Episteride 诱导大鼠腹侧前列腺萎缩和凋亡。 | |||
T6019 |
Volasertib
BI 6727,伏拉塞替 |
Apoptosis; PLK | Apoptosis; Cell Cycle/Checkpoint |
Volasertib (BI 6727) 是一种具有口服活性的高效ATP 竞争性Polo 样激酶 1 抑制剂。它抑制 PLK2 和 PLK3,IC50分别为 5 和 56 nM。它是二氢蝶呤酮衍生物,有抗肿瘤活性,可诱导有丝分裂停滞和细胞凋亡。 | |||
T35407 |
Ζ-Stat
|
PKC | Chromatin/Epigenetic; Cytoskeletal Signaling |
ζ-Stat 是非典型的、特异性的PKC-ζ抑制剂,IC50为 5 μM。ζ-Stat 能够减少黑色素瘤细胞系的增殖并诱导细胞凋亡,在体外显示除抗肿瘤活性。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3339 |
Sophoridine
5-Epidihydrosophocarpine,槐定碱,Dihydro-5-episophocarpine |
Apoptosis; Topoisomerase | Apoptosis; DNA Damage/DNA Repair |
Sophoridine (Dihydro-5-episophocarpine) 是一种从豆科植物槐豆斜生植物的叶子中分离出来的喹喔啉生物碱。它是胰腺癌的候选药物,诱导细胞凋亡。 | |||
TN3110 |
5-Geranoxy-7-methoxycoumarin
|
Anti-infection; Antibacterial; Antifungal | Microbiology/Virology |
5-Geranoxy-7-methoxycoumarin 是一种香豆素。它诱导细胞凋亡,具有抗癌、抗真菌和抗菌活性。 | |||
T3676 |
Sesamol
1,3-Benzodioxol-5-ol,3,4-Methylenedioxyphenol,芝麻酚 |
Apoptosis; AMPK | Apoptosis; Chromatin/Epigenetic; PI3K/Akt/mTOR signaling |
Sesamol (1,3-Benzodioxol-5-ol) 是芝麻油的主要成分,具有抗氧化和抗肿瘤活性。它是一种自由基清除剂,在 DPPH 实验中,IC50为 5.95±0.56 μg/mL。 | |||
T3843 |
Pinosylvin
银松素,3,5-stilbenediol,5-Styrylresorcinol |
Apoptosis; Others; Antibacterial; Autophagy | Apoptosis; Autophagy; Microbiology/Virology; Others |
Pinosylvin (5-Styrylresorcinol) 是从Pinus spp 的心材中分离出来的一种白藜芦醇类似物,可诱导白血病细胞凋亡和自噬。它是一种感染前的类苯乙烯类毒素,具有抗菌活性。 | |||
TN1560 |
Dehydroeffusol
去氢厄弗酚,5-Ethenyl-1-Methylphenanthrene-2,7-Diol,Dehydro Effusol |
MMP; ERK; GPR; Others | Endocrinology/Hormones; GPCR/G Protein; MAPK; Others; Proteases/Proteasome |
Dehydroeffusol (Dehydro Effusol) 通过选择性诱导肿瘤抑制性内质网应激和中度细胞凋亡来抑制胃癌细胞生长和致瘤性,具有抗癌、抗焦虑和镇静作用。 | |||
T8227 |
5'-Methylthioadenosine
Methylthioadenosine,5-脱氧-5-甲硫腺苷,5'-(Methylthio)-5'-deoxyadenosine,5'-Deoxy-5'-(methylthio)adenosine,5'-S-Methyl-5'-thioadenosine |
Endogenous Metabolite | Metabolism |
5'-Methylthioadenosine (Methylthioadenosine) 是由 S-腺苷蛋氨酸在多胺合成过程中生成的核苷,通过抑制肿瘤细胞增殖、侵袭和诱导细胞凋亡来抑制肿瘤,同时控制肿瘤组织的炎症微环境。 | |||
TN1684 |
Ginsenoside F5
人参皂苷 F5,人参皂苷F5 |
Apoptosis | Apoptosis |
Ginsenoside F5 是从人参中提取的一种天然产物,通过凋亡途径显着抑制 HL-60 细胞的生长。 | |||
T1659 |
Melatonin
Melatonine,松果体素,N-Acetyl-5-methoxytryptamine,褪黑素 |
CaMK; Apoptosis; Mitophagy; Estrogen/progestogen Receptor; Melatonin Receptor; Glutathione Peroxidase; Endogenous Metabolite; ROR; Autophagy | Apoptosis; Autophagy; Endocrinology/Hormones; GPCR/G Protein; Metabolism; Neuroscience |
Melatonin (Melatonine) 是一种由松果体制成的激素,可激活褪黑激素受体。它在睡眠中起作用,有抗氧化和抗炎特性。它是新型选择性ATF-6抑制剂,可诱导细胞凋亡。 | |||
T0136 |
Citicoline
CDP-Choline,Citicholine,尼古林,cytidine 5'-diphosphocholine,cytidine diphosphate-choline |
Apoptosis; Dopamine Receptor; Endogenous Metabolite | Apoptosis; GPCR/G Protein; Metabolism; Neuroscience |
Citicoline (CDP-Choline) 是一种合成细胞膜组分磷脂酰胆碱的中间体,有神经保护作用。 | |||
T1662 |
5-Aminolevulinic acid hydrochloride
氨基酮戊酸,Hydrangin,5-ALA,5-Aminolevulinic acid HCl,5-氨基乙酰丙酸盐酸盐,ALA hydrochloride |
Apoptosis; Mitophagy; Endogenous Metabolite; Autophagy | Apoptosis; Autophagy; Metabolism |
5-Aminolevulinic acid hydrochloride (5-ALA) 是体内血红素生物合成的中间体,也是四吡咯的通用前体。 | |||
TN1465 |
Cannabigerol
|
NOS; 5-HT Receptor; ROS | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Cannabigerol 是一种植物大麻素,是一种高亲和力 α2-肾上腺素能受体激动剂、中度亲和力 5-HT1A 受体拮抗剂和低亲和力 CB1/CB2受体拮抗剂。它可降低眼压,有潜力治疗青光眼。 | |||
TN1237 |
3-O-Methylgallic acid
3,4-Dihydroxy-5-methoxybenzoic acid,3-O-甲基没食子酸 |
Apoptosis; NF-κB; OCT; DNA/RNA Synthesis; STAT | Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; JAK/STAT signaling; Membrane transporter/Ion channel; NF-κB; Stem Cells |
3-O-Methylgallic acid (3,4-Dihydroxy-5-methoxybenzoic acid) 是一种花青素代谢产物,具有强大的抗氧化能力。它还诱导细胞凋亡并具有抗癌作用,可抑制 Caco-2 细胞增殖,IC50值为 24.1 μM。 | |||
T1508 |
Decitabine
Dacogen,NSC 127716,地西他滨,Deoxycytidine,5-Aza-2'-deoxycytidine |
Apoptosis; Nucleoside Antimetabolite/Analog; DNA Methyltransferase | Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; DNA Damage/DNA Repair |
Decitabine (Deoxycytidine) 是脱氧胞苷类似物,一种 DNA 甲基转移酶抑制剂,具有口服活性。Decitabine 具有抗肿瘤活性和抗代谢活性。Decitabine 诱导细胞周期阻滞和凋亡。 | |||
T3S0153 |
Xanthatin
苍耳亭,叶黄制菌素 |
Apoptosis; VEGFR; Lipoxygenase; Wnt/beta-catenin; Antibacterial | Angiogenesis; Apoptosis; Cytoskeletal Signaling; Metabolism; Microbiology/Virology; Stem Cells; Tyrosine Kinase/Adaptors |
Xanthatin 是一种从Xanthium strumarium 叶子中提取的天然产物,可诱导细胞凋亡。它抑制布鲁氏菌的IC50值为 2.63 μg/ mL,对寄生虫特异性锥虫硫磷还原酶具有不可逆的弱抑制作用。它通过抑制PGE2的合成和 5-脂氧合酶的活性而显示出抗炎活性。 | |||
T8296 |
5,7,4'-Trimethoxyflavone
5,7,4'-三甲氧基黄酮,芹菜素三甲醚,4',5,7-三甲氧基黄酮,4',5,7-Trimethoxyflavone |
Apoptosis; PARP; Caspase | Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Proteases/Proteasome |
5,7,4'-Trimethoxyflavone (4',5,7-Trimethoxyflavone) 是从泰国著名的药用植物 Kaempferia parviflora 中分离出来的一种天然产物。它以浓度依赖性方式显著有效抑制 SNU-16 人胃癌细胞的增殖,诱导细胞凋亡。 | |||
T3551 |
D-Pantothenic acid hemicalcium salt
泛酸钙,D-Pantothenic Acid Calcium,D-泛酸半钙,Calpanate,Calcium D-pantothenate,Vitamin B5 calcium salt,Calcium pantothenate,Calcium D-Panthotenate |
Apoptosis; Endogenous Metabolite | Apoptosis; Metabolism |
D-Pantothenic acid hemicalcium salt (Calcium pantothenate) 是一种水溶性维生素,能够减少苹果汁中的棒曲霉素。 | |||
T1208 |
Citicoline sodium
Citicoline sodium salt,CDP-choline,胞磷胆碱钠 |
Apoptosis; Others; Endogenous Metabolite | Apoptosis; Metabolism; Others |
Citicoline sodium (CDP-choline) 是一种合成细胞膜组分磷脂酰胆碱的中间体,有神经保护作用。 | |||
T4S0498 |
Glaucocalyxin A
蓝萼甲素,Wangzaozin B,Leukamenin F |
Apoptosis; Akt; Caspase; PI3K | Apoptosis; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Proteases/Proteasome |
Glaucocalyxin A (Leukamenin F) 是来自日本黑纹病菌的一种对映型月桂基二萜,具有抗肿瘤作用。它通过调节PI3K/Akt 信号通路抑制 GLI1 的核易位,诱导骨肉瘤凋亡。 | |||
T2P2923 |
Stearic acid
硬脂酸,Isostearic acid,Octadecanoic acid,Cetylacetic acid |
Phosphatase; Endogenous Metabolite | Metabolism |
Stearic acid (Cetylacetic acid) 是长链饱和脂肪酸,存在于许多动植物油脂中。 | |||
T4S2126 |
Ginkgetin
银杏双黄酮,银杏素 |
Apoptosis; Wnt/beta-catenin; COX; STAT; Autophagy | Apoptosis; Autophagy; Cytoskeletal Signaling; Immunology/Inflammation; JAK/STAT signaling; Neuroscience; Stem Cells |
Ginkgetin 是从银杏叶中分离得到的一种双黄酮,具有抗肿瘤、抗炎、神经保护、抗真菌的作用。它也是 Wnt 信号抑制剂,IC50值为 5.92 μM。 | |||
T14121 |
Actinonin
(-)-Actinonin |
Aminopeptidase | Metabolism |
Actinonin ((-)-Actinonin) is a naturally occurring antibacterial agent produced by Actinomyces and a potent reversible peptide deformylase (PDF) inhibitor with a Ki of 0.28 nM, it also is an apoptosis inducer. Actinonin inhibits aminopeptidase M, aminopeptidase N and leucine aminopeptidase, it also inhibits MMP-1, MMP-3, MMP-8, MMP-9, and hmeprin α with Ki values of 300 nM, 1,700 nM, 190 nM, 330 nM, and 20 nM, respectively. Actinonin has antiproliferative and antitumor activities[1][2][3][4][5]. | |||
T36179 |
Aspulvinone O
|
||
Aspulvinone O is a fungal metabolite that has been found in P. variotti and has antioxidant and anticancer activities.1,2 It scavenges 2,2-diphenyl-1-picrylhydrazyl radicals in a cell-free assay (IC50 = 11.6 μM).1 Aspulvinone O inhibits aspartate transaminase 1 (GOT1; Kd = 3.32 μM) and is cytotoxic to PANC-1, AsPC-1, and SW1990 pancreatic cancer cells (IC50s = 20.54-26.8 μM).2 It reduces the oxygen consumption rate (OCR) and induces apoptosis in SW1990 cells. Aspulvinone O (2.5 and 5 mg/kg) redu... |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-02519 |
API5 Protein, Mouse, Recombinant (His & Myc)
Api5,AAC-11,Apoptosis inhibitor <... |
Mouse | E. coli |
Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. | |||
TMPH-02533 |
BIRC5 Protein, Mouse, Recombinant (His)
BIRC5,Baculoviral IAP repeat-containing protein |
Mouse | P. pastoris (Yeast) |
BIRC5 Protein, Mouse, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 18.3 kDa and the accession number is O70201. | |||
TMPH-02532 |
BIRC5 Protein, Mouse, Recombinant (E. coli, His)
Apoptosis inhibitor 4,Apoptosis <... |
Mouse | E. coli |
BIRC5 Protein, Mouse, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 22.3 kDa and the accession number is O70201. | |||
TMPH-00992 |
BIRC5 Protein, Human, Recombinant (His & SUMO)
API4,Apoptosis inhibitor survivin,BIRC... |
Human | E. coli |
BIRC5 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli. | |||
TMPY-05308 |
CD45 Protein, Human, Recombinant (aa 1-529, His)
GP180,B220,L-CA,protein tyrosine phosphatase, receptor type,... |
Human | HEK293 Cells |
CD45 Protein, Human, Recombinant (aa 1-529, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 57.4 kDa and the accession number is P08575-5. | |||
TMPH-02654 |
FGF-5 Protein, Mouse, Recombinant (His)
|
Mouse | E. coli |
Plays an important role in the regulation of cell proliferation and cell differentiation. Required for normal regulation of the hair growth cycle. Functions as an inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase. FGF-5 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 32.8 kDa and the accession number is P15656. | |||
TMPH-01335 |
FGF-5 Protein, Human, Recombinant (GST & His & Myc)
|
Human | E. coli |
Plays an important role in the regulation of cell proliferation and cell differentiation. Required for normal regulation of the hair growth cycle. Functions as an inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase. FGF-5 Protein, Human, Recombinant (GST & His & Myc) is expressed in E. coli expression system with N-10xHis-GST and C-Myc tag. The predicted molecular weight is 62.4 kDa and the ... | |||
TMPY-00725 |
COMP Protein, Human, Recombinant (His)
THBS5,MED,EPD1,PSACH,cartilage oligomeric matrix pr... |
Human | HEK293 Cells |
Cartilage Oligomeric Matrix Protein (COMP), also referred to as Thrombospondin-5, is a non-collagenous extracellular matrix (ECM) protein and belongs to the subgroup B of the thrombospondin protein family. This protein is expressed primarily in cartilage, ligament, and tendon, and binds to other ECM proteins such as collagen I, II and IX with high affinities depending on the divalent cations Zn2+ or Ni2+. COMP is a secreted glycoprotein that is important for growth plate organization and functio... | |||
TMPY-05387 |
SLAMF7 Protein, Human, Recombinant (hFc)
SLAM family member 7,19A,SLAM7,CS1,CD319,CRACC |
Human | HEK293 Cells |
SLAMF7 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 49.1 kDa and the accession number is Q9NQ25-5. | |||
TMPY-04318 |
GRIK2 Protein, Human, Recombinant (hFc)
GLUR6,EAA4,MRT6,GLR6,glutamate receptor, ionotropic, kainate... |
Human | HEK293 Cells |
GRIK2 (Glutamate Ionotropic Receptor Kainate Type Subunit 2, also known as GluR6) is a Protein Coding gene. The GRIK2 (one of the kainate receptors) gene resides in a genetic linkage region (6q21) associated with bipolar disorder (BPD). The gene coding for GRIK2 has been suggested as a candidate gene for autism based on its localization in the autism-specific region on chromosome 6q21 and the involvement of receptor protein in cognitive functions like learning and memory. GRIK2 belongs to the gl... | |||
TMPY-05547 |
SLAMF7 Protein, Human, Recombinant (hFc), Biotinylated
CS1,SLAM7,CD319,SLAM family member 7,CRACC,19A |
Human | HEK293 Cells |
SLAMF7 Protein, Human, Recombinant (hFc), Biotinylated is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 49.1 kDa and the accession number is Q9NQ25-5. | |||
TMPJ-00854 |
ETS1 Protein, Human, Recombinant (His)
V-ets Erythroblastosis Virus E26 Oncogene Homolog 1 (Avian),... |
Human | E. coli |
ETS1 Protein (ETS1) is a nuclear protein that belongs to the ETS family. Members of this family recognize the core consensus DNA sequence GGAA/T in target genes. Proteins function either as transcriptional activators or repressors of numerous genes. They are involved in stem cell development, cell senescence and death, and tumorigenesis. ETS1 is a transcription factor, containing one ETS DNA-binding domain and one PNT (pointed) domain. it has been shown to interact with TTRAP, UBE2I and Death As... | |||
TMPY-05498 |
SR-BI/SCARB1 Protein, Human, Recombinant (hFc)
HDLQTL6,SR-BI,SRB1,CD36L1,CLA-1,CLA1,scavenger receptor clas... |
Human | HEK293 Cells |
SR-BI/SCARB1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 73.4 kDa and the accession number is Q8WTV0-5. | |||
TMPK-01357 |
SIRP alpha V5 Protein, Human, Recombinant (His & Avi)
MFR,PTPNS1,P84,BIT,MYD-1,MYD1,SHPS-1,SIRPA,SIRP α,SIRP α V |
Human | HEK293 Cells |
Signal regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons.SIRPα acts as inhibitory receptor and interacts with a broadly expressed transmembrane protein CD47 also called the "don´t eat me" signal. | |||
TMPK-01363 |
SIRP alpha V5 Protein, Human, Recombinant (His & Avi), Biotinylated
SIRP alpha,MFR,PTPNS1,SIRP α V5,P84,SHPS-1,BIT,CD17... |
Human | HEK293 Cells |
Signal regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons.SIRPα acts as inhibitory receptor and interacts with a broadly expressed transmembrane protein CD47 also called the "don´t eat me" signal.Cancer cells highly expressed CD47 that activate SIRP α and inhibit macrophage-mediated destruction. SIRP alpha V5 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian c... |